N-(1-(4,5-dibromo-3,6-dioxo-2-(prop-2-yn-1-yl)-3,6-dihydropyridazin-1(2H)-yl)-2-oxo-7,10,13-trioxa-3-azahexadecan-16-yl)-1-fluorocyclooct-2-yne-1-carboxamide CC-6084 Site-specific and hydrophilic ADCs through

Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG

Site-specific Conjugation

1039/C6MB00138F Keywords: Biotinylation Reagent

e202116078

1094-1101 DOI: 10

N-(1-(4,5-dibromo-3,6-dioxo-2-(prop-2-yn-1-yl)-3,6-dihydropyridazin-1(2H)-yl)-2-oxo-7,10,13-trioxa-3-azahexadecan-16-yl)-1-fluorocyclooct-2-yne-1-carboxamide CC-6084 Site-specific and hydrophilic ADCs throughReferences: Maruani, A.; et al. A plug and play approach to antibody based therapeutics via a chemoselective dual click strategy Nat. Commun. (2015), 6, 6645 6653 DOI: 10. 1038 ncomms7645 Keywords: Antibody Conjugates; Dibromopyridazinedione; Re bridging